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AIH

What is Autoimmune Hepatitis (AIH)?

Autoimmune Hepatitis (AIH) is a chronic disorder where the immune system wrongly attacks liver cells, causing inflammation and scarring. Without timely AIH diagnosis and treatment, it can progress to cirrhosis or liver failure. At Liver Surgeons, Delhi’s premier AIH center, we specialize in halting disease progression and improving quality of life through cutting-edge therapies.

Key Risk Groups

  • Women (75% of cases)
  • Patients with other autoimmune disorders (e.g., thyroiditis, rheumatoid arthritis).
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Autoimmune Hepatitis

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Diagnosis of Autoimmune Hepatitis

1. Blood Tests

  • ANA (Antinuclear Antibodies): Present in 80% of Type 1 AIH cases.
  • Anti-LKM Antibodies: Specific to Type 2 AIH (common in children).
  • IgG Levels: Elevated in 85% of patients.

2. Liver Biopsy

  • Purpose: Confirms inflammation severity and fibrosis stage.
  • Process: Ultrasound-guided needle biopsy (results in 48 hours).

3. Overlap Syndromes

PBC (Primary Biliary Cholangitis) and PSC (Primary Sclerosing Cholangitis): Require tailored therapies combining AIH and cholestasis management.

Autoimmune Hepatitis Treatment

1. Immunosuppression Therapy

  • First-Line:
    • Prednisone: Reduces inflammation (initial high dose, tapered over weeks).
    • Azathioprine: Maintenance therapy to prevent relapses.
  • Second-Line: Mycophenolate mofetil for non-responders.

2. Managing AIH Flare-Ups

  • Symptoms: Jaundice, fatigue, elevated ALT/AST.
  • Action: Temporary steroid boosts + closer monitoring.

3. Pregnancy & AIH

  • Preconception Care: Stabilize AIH for 6+ months before conception.
  • During Pregnancy: Safe immunosuppressants (e.g., prednisone) and frequent LFTs.

Why Choose Liver Surgeon in Delhi/India?

  • Dr. Ashish George: Renowned AIH specialist with 15+ years of expertise in managing complex cases, including overlap syndromes and pregnancy-related AIH. Pioneered 200+ successful remission cases.
  • Advanced Diagnostics:
    • Genomic Testing: Identifies genetic markers for personalized therapy.
    • Transient Elastography: Tracks fibrosis without repeated biopsies.
  • Holistic Care:
    • Nutritionists design anti-inflammatory diets.
    • Mental health support for chronic disease management.
  • Proven Outcomes:
    • 90% remission rate with azathioprine/prednisone therapy.
    • 80% reduction in flare-ups under our care.

Success Stats:

  • 95% accuracy in AIH diagnosis via antibody panels.
  • 70% lower steroid dependency with early intervention.

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AIH CONCERNS

Autoimmune Hepatitis FAQs

While not curable, proper treatment with immunosuppressants achieves long-term remission in 90% of patients. Regular monitoring helps maintain stable liver function.

AIH results from the immune system attacking liver cells, requiring immunosuppressants. Viral hepatitis needs antivirals. Diagnosis involves specific antibody tests (ANA/anti-LKM) at our Delhi lab.

Essential dietary guidelines:
• Strict alcohol avoidance
• Limit processed foods and salt
• Increase antioxidant-rich foods
Our Delhi nutritionists create personalized meal plans to support liver health during treatment.

Low-dose prednisone (<20mg/day) is generally safe. Our specialists recommend:
• Timing doses 4 hours before feeding
• Monitoring baby for unusual drowsiness
• Regular follow-ups to adjust medication

While blood tests suggest AIH, Dr. Ashish George's team recommends biopsies to:
• Confirm inflammation severity
• Rule out overlap syndromes (PBC/PSC)
• Guide treatment intensity
Our ultrasound-guided biopsies minimize discomfort with 99% diagnostic accuracy.

Yes, with proper management:
• Pre-conception counseling to adjust medications
• Monthly liver function monitoring
• Safe doses of azathioprine/prednisone
Our Delhi team has successfully managed 100+ AIH pregnancies with optimal outcomes.

Key differences:
AIH: Attacks liver cells, treated with immunosuppressants
PBC/PSC: Targets bile ducts, needs ursodeoxycholic acid
Overlap syndromes: Require combined therapy - a specialty of our Delhi center

Dr. Ashish George's team manages risks through:
• Gradual dose reduction after remission
• Bone density protection (calcium/vitamin D)
• Early transition to azathioprine
• Regular monitoring for diabetes/osteoporosis
Our protocols minimize side effects while maintaining treatment efficacy.